Connecting the Dots Between Obesity and Dementia

An observational study published in the March 26, 2008, issue of Neurology found an association between obesity in midlife and an increased risk of late life dementia. The study was based on data collected in the 1960s and '70s, when doctors at Kaiser Permanente of Northern California measured the midsections of 6,583 members of the health group.

The researchers found that people with larger midsections and normal Body Mass Index (BMI), a measure comparing weight to height, had an increased risk of late life dementia compared to those with smaller midsections and normal BMI. People who exhibited both obesity and larger midsections had the highest risk of dementia.

The mechanisms linking obesity to dementia are not well understood. The excess fat may increase blood glucose, which could conceivably affect brain function. And it goes without saying that large stomachs may be a proxy for reduced vascular health, which could affect the brain and other organ systems.

In interpreting this study, we should be careful not to focus exclusively on large stomachs as a simple causal factor at the expense of understanding the social environments that encourage unhealthy behaviors that, in turn, promote obesity.

Indeed, there are a wide range of influences in our surroundings -- service sector jobs requiring greater time commitments and less physical movement, faster paced lives and motorized transportation that discourage walking, easy access to cheap, unhealthy, fast foods, increasing levels of stress, disparities in income -- that promote obesity in individuals or populations.Some have termed our modern environments "obesogenic" for their propensity to encourage behaviors that cause us to take in more calories and move less. Promoting nutritional change will be impossible without first understanding the food meanings, practices and beliefs, and the factors that might constrain them, within a particular group.

That said, there are commonsense steps we can take to lessen the impact of the obesity epidemic. Any approach should begin with a recognition of basic human physiology. Human beings, having evolved as hunter-gatherers, are engineered to spend our days moving and to eat a wide, bio-diverse range of (non-processed) foods. Fighting the obesity epidemic, which is not just afflicting developed countries but also developing nations, requires that all of us take pause and consider how we can make both small changes in our own lives and larger societal changes that will make us healthier as individuals, families, and communities.Are we putting healthy foods in our bodies?Are we moving our bodies as they were intended to be moved?Do social and economic conditions give everyone a fair chance to have a healthy body?These are the questions we must begin to ask.
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