Medications and Pregnancy

When a woman asks if it's safe to take a particular drug during pregnancy, there is rarely a definite yes or no answer. The key to taking medications during pregnancy—or when you're trying to get pregnant—is weighing the benefits of the medicine against the potential risks to the fetus.

Be Proactive and Ask Questions

When possible, think ahead. It’s best to address questions about medications and vitamins before you are pregnant. Ask your healthcare provider about the over-the-counter medications you currently use. These include drugs for everyday conditions, such as heartburn, allergies , or headaches . In addition, check with your healthcare provider about any prescription medications you currently take. Both types of medications may need to be either discontinued or changed before you get pregnant.

The Role of Teratology Specialists

The Organization of Teratology Information Services (OTIS) provides expert information about prenatal exposures to medications, chemicals, and other substances. OTIS member organizations don't prescribe or recommend treatments; they provide objective information about the following:

  • Medications a woman took before she realized she was pregnant
  • Medications prescribed for an illness that occurs during pregnancy
  • Medications for chronic conditions

FDA Safety Rating

The US Food and Drug Administration (FDA) currently requires that drugs be categorized according to their risk to pregnant women.. However, Gangell and Ruggiero have stated that the categories are not detailed enough to be useful. The FDA is currently working on a new approach to assess the safety of medications for pregnant women.

Note on Herbs and Supplements

Dr. Ruggiero warns pregnant women not to take herbal remedies or supplements, because there are no reliable studies about their effects during pregnancy. Since they are not regulated the way conventional medications are, there is no way to gauge the purity or actual dose of the substance you're taking. There may be many alternative and complementary therapies that are safe and/or helpful in pregnancy. But you need to do your research to find out if there is safety in pregnancy information, and physicians recommend that you discuss these modalities with them as well.

An excellent resource about both drugs and complementary modalities is the Motherrisk Program hosted by the Hospital for Sick Children in Toronto, Canada.

RESOURCES:

Organization of Teratology Information Services (OTIS)
http://otispregnancy.org/

WomensHealth.gov
US Department of Health & Human Services
http://4woman.gov/

References:

Allaire AD, Moos MK, Wells SR. Complementary and alternative medicine in pregnancy: a survey of North Carolina certified nurse-midwives. Obstet Gynecol. 2000;95:19-23.

Gibson PS, Powrie R, Star J. Herbal and alternative medicine use during pregnancy: a cross-sectional survey. Obstet Gynecol. 2001;97:S44-S45.

Meadows M. Pregnancy and the drug dilemma. Food and Drug Administration website. FDA Consumer Magazine. May-June 2001. Available at: http://www.fda.gov/fdac/features/2001/301_preg.html.

Scialli AR. The Organization of Teratology Information Services (OTIS) registry study. Journal of Allergy and Clinical Immunology. 1999;103:373-376.




Last reviewed June 2007 by Jeff Andrews, MD, FRCSC, FACOG

Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.

Source: EBSCO
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