Pronounced: ay-men-or-EE-uh
More InDepth Information on This ConditionEn Espaol (Spanish Version)Definition
Amenorrhea refers to the absence of a menstrual cycle. Primary amenorrhea occurs if an adolescent female has not yet begun menstruation by around age 16 or so. Secondary amenorrhea describes a condition in which a woman who has previously menstruated on a regular basis misses three or more periods in a row. In the United States, amenorrhea affects between 2-5% of women.
Most females begin menstruating between the ages of 9-18, but age 12 is the average. Menstruation, or a menstrual period, refers to the monthly process in which the uterus sheds blood and tissue in preparation for pregnancy.
If a female has not started her menstrual period by age 16, a doctor should be contacted to determine the cause and prescribe any treatment that may be necessary.
Menstrual Flow
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Causes
Secondary amenorrhea is most commonly caused by pregnancy. But in nonpregnant women, amenorrhea may result from a variety of factors, including an existing medical condition, lifestyle, emotional distress, hormonal irregularity, or medication. Every effort should be made to determine the exact cause. Specific causes of amenorrhea include:
Dramatic weight loss, particularly from drastic diets, eating disorders including anorexia and bulimia , or excessive exercise Dramatic weight gain or morbid obesityMalnourishmentBirth defects including lack of a uterus, vagina, or other reproductive organs Medical conditions including cystic fibrosis , Cushing's disease , polycystic ovary , or Prader-Willi syndromePsychological stresscan lead to a hormonal imbalance sufficient to cause amenorrhea.Medicationssome antidepressants, chemotherapeutics, corticosteroids, certain contraceptives.Chromosomal abnormalitiesHermaphroditism (having both male and female reproductive organs)Pituitary tumorThyroid dysfunctionUterine scarring Risk FactorsWomen who eat a diet that doesnt provide sufficient caloric intake, exercise excessively, or suffer under considerable psychological distress are more likely to experience amenorrhea.Women born with chromosomal or hormonal abnormalities, as well as those who suffer from certain chronic diseases, are also more likely to experience amenorrhea. SymptomsThe main symptom of primary amenorrhea is the absence of a menstrual period in girls age 16 or older. The main symptom of secondary amenorrhea is three or more missed periods in a row in a woman who has previously had a regular period.
If you experience any of these symptoms, dont assume that the cause of your amenorrhea is something serious. If youre sexually active, the first thing to do is to determine if youre pregnant. Then see your physician to get a proper diagnosis. DiagnosisYour doctor will ask about your symptoms and medical history, and perform a physical exam. Tests may include the following: Pregnancy testBlood work to determine hormone levelsChromosome test to determine if any abnormalities existUrine testProgestin challenge test (taking progestogen for 7-10 days to trigger bleeding in order to determine if lack of estrogens is responsible for amenorrhea)CT scan of the head a type of x-ray that uses a computer to make pictures of structures of the head, brain, and skull MRI (magnetic resonance imaging ) scan of the head a test that uses magnetic waves to make pictures of brain tissue Ultrasound use of high-frequency sound waves to view and examine the organs of the abdominal cavity Laparoscopy insertion of a thin tube affixed with a light and camera, along with other instruments, through a tiny incision in the abdominal wall All or even most of these tests are rarely indicated.
Treatment Treatment for amenorrhea is dependent upon the cause of the condition: Congenital birth defectmay be correctable by surgery Pituitary tumortreatments usually involve surgery or radiation therapyHormonal irregularityhormone therapy, including oral contraceptives, may cause menstruation to beginWeight relatedimproved diet, including healthy caloric intake and a reasonable exercise routine usually restores hormonal balance and menstruationMedical conditionif effective treatment is available, it may restore menstruation PreventionMany cases of amenorrhea are unavoidable with the notable exceptions of pregnancy, eating disorders, and cases related to medications. Use effective contraception if you are sexually active and maintain a healthy body weight through a reasonable diet and exercise regimen. Seeking help during time of stress may also help prevent a bout of amenorrhea. RESOURCES: New York Methodist Hospitalhttp://www.nym.org/healthinfo/docs/101/doc101treatments.html United States Department of Health and Human Services, National Women's Health Information Centerhttp://www.womenshealth.gov/faq/menstru.htm United States National Library of Medicinehttp://www.nlm.nih.gov/medlineplus/ency/article/001218.htm#Treatment
University of Michigan Health Systemhttp://www.med.umich.edu/1libr/aha/aha_amenor_crs.htm CANADIAN RESOURCES: BC Health Guidehttp://www.bchealthguide.org The Society of Obstetricians and Gynaecologists of Canada (SOGC)http://www.sogc.org/index_e.asp References: Amenorrhea. Epigee Women's Health website. Available at: http://www.epigee.org/menstruation/amenorrhea.html. Accessed September 14, 2006. Amenorrhea: What you should know. American Academy of Family Physicians website. Available at: http://familydoctor.org/885.xml. Accessed September 14, 2006. Laufer, MR, Floor, AE, Parsons, KE, et al. Hormone testing in women with adult-onset amenorrhea. Gynecol Obstet Invest . 1995; 40:200. Perkins, RB, Hall, JE, Martin, KA. Neuroendocrine abnormalities in hypothalamic amenorrhea: spectrum, stability, and response to neurotransmitter modulation. J Clin Endocrinol Metab . 1999; 84:1905. Reindollar, RH, Novak, M, Tho, SP, McDonough, PG. Adult-onset amenorrhea: a study of 262 patients. Am J Obstet Gynecol . 1986; 155:531. Last reviewed February 2008 by Marcin Chwistek, MDPlease be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.
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