Anemia of Chronic Disease (Anemia of Inflammation, Hypoferremia of Inflammatory Disease, ACD)

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The presence of certain chronic medical conditions, such as cancer , and infectious and inflammatory diseases, can lead to the development of anemia. Anemia is a blood disorder occurring when abnormally low levels of red blood cells are found in the blood.

With anemia of chronic disease (ACD), the body cannot effectively use iron to make new red blood cells even though levels of stored iron in the bodys tissue are normal or high. As a result, the number of healthy new red blood cells gradually falls. Similarly, levels of hemoglobin, the component of red blood cells that carries oxygen to the tissues and muscles, also drop. Although ACD is the second most common form of anemia. It is rarely severe.


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Other illnesses contribute to the development of ACD including:

Risk Factors

Anyone of any age with a chronic inflammatory or infectious disease may be at risk for ACD, but the elderly are among those at highest risk.

Symptoms ACD usually develops slowly producing few or no symptoms. When symptoms do occur, they are usually mild. Symptoms include: Pale complexion, dizziness, fatigue, and rapid heartbeatInfection, fever (even mild) Diagnosis Your doctor will ask about your symptoms and medical history, particularly any history of chronic inflammatory or infectious disease or cancer, and perform a physical exam. Blood tests may include: Red blood cell countHemoglobin levelSerum iron levelSerum ferritin levelSerum transferrin receptor levelTransferrin iron binding capacityTotal iron binding capacity (TIBC) Because iron stores will be elevated in the bone marrow, a bone marrow biopsy may also be performed. Treatment With ACD, if the underlying disease causing it is found and treated, the anemia may improve or clear on its own. Iron supplements and vitamins are generally not effective. For the unusual severe case of ACD, blood transfusions may be helpful. Additionally, drugs that help stimulate growth of new red blood cells, like erythropoietin, may be given temporarily. These drugs do have risks that are important to consider before treatment. * PreventionIf you have a chronic medical condition, continue prescribed treatment and maintain regular visits with your doctor.
RESOURCES: Iron Disorders Institute National Anemia Action Council CANADIAN RESOURCES: Anemia Institute Chronic Disease ManagementBritish Columbia Ministry of Health References: Beutler E. Unlocking the mysteries of iron homeostasis and of the anemia of chronic disease: is hepcidin the key? Blood . 2003;102:775. Medline Plus. National Library of Medicine website. Available at . Accessed July 15, 2005. Merck Manual of Medical Information, Second Home Edition Online . Merck and Co, Inc. website. Available at . Accessed July 15, 2005. Weiss G, Goodnough, LT. Anemia of chronic disease. NEJM . 2005;352:1011-1023. *3/12/2008 DynaMed Systematic Literature Surveillance DynaMed's Systematic Literature Surveillance : Bennett CL, Silver SM, Djulbegovic B, et al. Venous thromboembolism and mortality associated with recombinant erythropoietin and darbepoetin administration for the treatment of cancer-associated anemia. JAMA. 2008;299:914-924.
Last reviewed January 2008 by Igor Puzanov, MDPlease be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.
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