Diabetes Insipidus Causes

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Causes of Diabetes Insipidus


ADH controls the amount of water reabsorbed by the kidneys. ADH is made in the hypothalamus of the brain. The pituitary gland , at the base of the brain, stores and releases ADH.

Pituitary Gland

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  • Central DI (up to 50% of cases, the cause is unknown) may be caused by:
    • A lack of ADH made in the brain due to a genetic defect
    • Damage to the hypothalamus or pituitary glands by surgery, infection, tumor, or head injury
    • Sickle Cell Anemia
  • NDI may be caused by:
    • Renal cells in the kidneys not being able to conserve water, which may be due to a genetic defect in some cases
    • Kidney diseases (such as Polycystic Kidney Disease )
    • Medications (such as lithium , amphotericin B , or demeclocycline )-the most common cause of diabetes insipidus


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