Nontoxic Nodular Goiter Causes

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Causes of Nontoxic Nodular Goiter


The exact causes of nontoxic goiter are not known. In general, goiters may be caused by too much or too little thyroid hormones. There is often normal thyroid function with a nontoxic goiter. Some possible causes of nontoxic goiter include:

  • Heredity (family history of goiters)
  • Regular use of medications such as lithium , propylthiouracil , phenylbutazone, or aminoglutethimide
  • Regular intake of substances (goitrogens) that inhibit production of thyroid hormone-common goitrogens include foods such as cabbage, turnips, brussel sprouts, seaweed, and millet
  • Iodine deficiency-Iodine deficiency is very rare in the US and other developed countries, due to the use of iodized table salt; this is a primary cause of goiter in other parts of the world, particularly in mountainous areas, or areas that experience heavy rainfall or flooding


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