A Bad Sign: People Who Can’t “Read” Others

Misunderstanding May Signal Dementia

Have you ever thrown out a snarky, sarcastic quip and had it misinterpreted as solid truth-telling? Well, there may be reason to be concerned for the person you’ve talked to. A new study shows people who can’t pick up on sarcasm or a straight-out lie, may be exhibiting an early sign of dementia.

For the study, researchers asked 175 people, over half of whom had dementia, to watch videos of two people talking. At different times in the tape one person would lie or say something sarcastic. The viewers were also given both verbal and nonverbal clues to help pinpoint the false or insincere statements. Next, the subjects were asked yes/no questions about what they had seen.

People suffering from Alzheimer's disease and a similar condition, frontotemporal dementia, were included in the study, as well as healthy individuals. Healthy people easily picked out the lies and sarcasm, but those with frontotemporal dementia found it hard to distinguish among lies, sarcasm and fact.

The researchers also found that patients with Alzheimer's performed better on this test.

The team used MRIs to make accurate maps of the brains of the subjects in the study. This allowed them to measure the volumes of different regions of the brain showing that the sizes of those regions correlated with the inability to detect sarcasm or lying.

Scientists explained that the ability to identify lies is centered in the frontal lobe of the brain, which diminishes in people with frontotemporal dementia. The results of the study were presented at the annual meeting of the American Academy of Neurology in Honolulu. Scientists estimate as many as 20,000 Americans have frontotemporal dementia. Some people with the condition undergo dramatic changes in their personality and become socially inappropriate, impulsive or emotionally indifferent, while others lose the ability to use and understand language. This kind of dementia is often misdiagnosed as a psychiatric problem or as Alzheimer's disease. But frontotemporal dementia tends to occur at a younger age than does Alzheimer's disease, typically between the ages of 40 and 70. The new “lie detector test” might one day help doctors decipher the true nature of their patient’s difficulty early on and plan a more effective treatment program. Robin Westen is ThirdAge’s medical reporter. Check for her daily updates. See what others have to say about this story or leave a comment of your own.
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