Botulinum Toxin Dysport Handles Crow's Feet Better than Botox

Botulinum toxin has a recently-approved alternative that beat anti-wrinkle treatment Botox in a recent trial comparing the two compounds' ability to erase crow's feet.

"One month after treatment, on a two-to-one preference basis, patients picked Dysport over the Botox in terms of wrinkle improvement," study co-author Dr. Corey S. Maas, an associate clinical professor at the University of California, San Francisco, as well as a plastic surgeon with The Maas Clinic, based in San Francisco and Lake Tahoe, told HealthDay News.

"So, we can say that when it comes to addressing the smile lines around the eyes, the crow's feet, at one month the Dysport is more effective than Botox," Maas continued. "And that's a big deal, because Botox is such a recognized household name now. And it's such a great drug. But when you have something that comes in that's as good in some areas, let alone even better, it's big news for all of us, both doctors and patients."

The Food and Drug Administration approved the first version of botulinum toxin type A in 2002. Manufactured by Allergan, Inc., this version is known as Botox.

An alternative version of the same toxin was approved in Europe in 1001 for general cosmetic applications. The drug, known as Dysport, is manufactured by Medicis Aesthetics and was approved for use in the United States in 2009.

The report did note that there was little difference between Botox and Dysport when it comes to the rest of the face.  "Now we want to be careful not to overplay this," Maas continued in her interview with HealthDay. "From our findings, it's clear that there's a better smoothing effect and clearing of lines around the eyes with Dysport. But does that also mean that Dysport is better at achieving the same thing around the mouth or forehead or neck? We really can't make that conclusion." "The cost of the two amounts respectively are about the same. Maybe actually a little bit less for Dysport, but not substantially less." Allergan Inc., issued a statement Monday that challenged the study findings on several grounds, including the limited size of the study, the shorter duration of the trial and the dosing ratio that the researchers used. "It is important to understand that no two botulinum toxins are alike and each has a unique molecular structure, formulation, potency and safety profile," the company said in its statement.
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