Can't Sleep? Insomnia Gene May Be to Blame

If you find yourself tossing and turning most nights, the culprit may be a newly discovered "insomnia gene." Yes, menopause can also play a part in keeping you awake, especially if you're prone to night sweats, but the mutated gene is a sleep disturber that affects you at any age and stage. If you're born with it, chances are you'll get two-thirds less shut-eye than normal over the long haul. Worse yet, that level of sleep deprivation carries with it serious health costs such as greater risks of diabetes and high blood pressure that can lead to a shortened lifespan.

The research was done on that laboratory favorite, the fruit fly, but scientists insist that the little insect has much in common with us when it comes to the mechanisms of sleep and wakefulness. Dr. Nicholas Stavropoulos of Rockefeller University in New York told MailOnline: "This work gives us several new clues about how sleep is controlled at the molecular level, and could prove useful in understanding and treating sleep disorders. But what's especially interesting is the insomniac gene may function through homeostatic mechanisms.These are distinct from the well-studied circadian clock pathways linked to sleep, and have an effect on the body regardless of the time of day."

So is there any hope for you if you are a chronic sheep-counter who never gets enough ZZZs? Yes, at least down the road. Dr. Stavropoulos and his team theorize that the so-called "insomnia gene" knocks out certain proteins in brain cells that help you doze off and stay asleep. When the scientists deleted the gene from brain cells but let it stay in the rest of the body, the insomniac fruit flies still didn't sleep well but they did live as long as their counterparts who enjoyed normal sleep patterns. As Dr. Stavropoulos put it: "This suggests reduced sleep can be 'uncoupled' from reduced lifespan, supporting the idea some disruptions of sleep do not effect overall health, at least as far as lifespan is concerned."
1 2 Next
Print Article