Cholesterol Drugs May Worsen Asthma, Small Study Finds

Cholesterol drugs may worsen asthma, after researchers found sufferers’ breathing worsened after they began using a statin drug to lower cholesterol.

Cholesterol drugs may worsen asthma, after a small study found that asthma sufferers’ breathing worsened after they began using a statin drug to lower cholesterol.

Asthma experts are surprised because previous studies have shown the drugs have anti-inflammatory properties that may help conditions like asthma.

The new study is to be presented at the annual meeting of the American College of Allergy, Asthma, and Immunology in Boston, reports WebMD.

Over the course of one year, the researchers followed 40 asthma patients who were treated at the same California clinic.

At the beginning of the study, twenty patients had just begun statin medications to lower cholesterol.

Twenty others who were not taking statins were followed for comparative purposes. All were nonsmokers who had been diagnosed with asthma for at least five years.

Patients were excluded from the study if an asthma attack had resulted in a hospital or emergency room admission in the eight months preceding the study, WebMD reports.

Other than asthma or high cholesterol, patients in the study were free of health problems, researchers say.

Doctors checked in with patients in the study every three months, asking about symptoms and medication use, as well as testing lung function.

After one year, patients taking statins performed 35 percent worse in a test of lung function than they did at the start of the study. Patients who were not taking statins also saw their lung function decline, but it was about 14 percent worse compared to how they performed at the start of the study. Those who were on statins also reported that they had used their rescue medications [inhalers] 72 percent more often than they had at the start of the study, reports WebMD. Patients on statins also reported getting up more frequently at night because of their asthma and said they had worse symptoms during the day. Those findings are associations, as the study was unable to prove that statins caused the increase in breathing problems. Lead researcher Safa M. Nsouli, MD, an allergist who is director of the Danville Asthma and Allergy Clinic, in Danville, Calif., stresses the preliminary study finding is not conclusive. He said the study is small and, as such, does not justify anyone ceasing to take a prescribed statin. "The goal of my study is to make aware the patients who have allergies and asthma to know that being on statins, this might imbalance their immune system and might ... adversely affect their asthma," he told WebMD.  
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