Fish Oil & Fatty Fish May Lower Risk of Age-Related Macular Degeneration

Regular consumption of fish oil, omega-3 fatty acids, and fish may significantly reduce the risk of developing age-related macular degeneration (AMD) in women, according to a report published today.

AMD is a common eye disease creating blind spots and blurred or distorted vision. According to the American Health Association Foundation, it is the leading cause of vision loss in Americans 60 years and older affecting an estimated 11 million people.

William G. Christen, Sc. D, of Brigham and Womens Hospital and Harvard Medical School both in Boston, Mass., worked with colleagues to collect data from 38,022 women who at the start of the study were not diagnosed with age-related macular degeneration.

In a questionnaire, they asked the women about their eating habits including intake of two omega-3 fatty acids, docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), and two omega-6 fatty acids, arachidonic acid and linoleic acid.

235 cases of AMD were recorded during ten years of follow-up involving more questionnaires tracking the womens eye health.

After accounting for age and treatment type, the researchers found women who consumed the most DHA had a 38 percent lower risk of developing age-related macular degeneration compared to women who consumed the least amount of DHA. The highest intake of EPA and the two other acids combined showed similar statistics.

One or more servings of fish per week, compared to less than one per month, showed 42 percent lower risk of AMD. Also, higher intake of linoleic acid, not arachidonic acid, showed an increase of AMD risk but the authors said the association was not significant after other risk factors and fats were considered. "In summary, these prospective data from a large population of women with no prior diagnosis of AMD indicate that regular consumption of DHA and EPA and fish significantly reduced the risk of incident AMD," stated the authors in the report. The authors said that consumption of canned tuna fish and dark-meat fish were the primary causes of lowering the risk of AMD. The study was published today online but will appear in the June issue of Archives of Ophthalmology, a journal of the American Medical Association (JAMA).
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