Nicotine Patch Proves Useful in Fighting Memory Loss

Positron Emission Tomography (PET) scans can show brain lesions usually associated with Alzheimers disease, aiding in diagnosing the disease.

The nicotine patch was designed to help smokers kick the habit by easing their nicotine addiction, but new research shows that the patch may help improve memory in older adults as well. According to ABC News, a small clinical trial from Vanderbilt University shows that people with mild cognitive impairment who wore the patch for six months showed a 46 percent improvement on long-term memory tests.

 For the study, researchers recruited 67 non-smokers with mild cognitive impairment and divided them into two groups. One group received a patch with 15 milligrams of nicotine, while the other received a placebo patch. The patches were replaced daily, and neither the patients nor the researchers knew which group was getting the drug.

Six months later, the study participants were tested for “normal performance” on long-term memory tests. Those who received the patch performed an average of 46 percent better, while those who received the placebo worsened by 26 percent.

The results have researchers excited as mild cognitive impairment is often considered a pre-cursor to Alzheimer’s disease.

“We’re pretty excited that we got a strong sign of improvement, and we think it has great implications going forward,” said study leader Paul Newhouse. “We reasoned that if it helps in early Alzheimer’s, we might be able to move back even further into patients with mild memory loss.”

ABC explained that nicotine works by stimulating receptors in neurons involved in learning and memory. While Alzheimer’s disease kills those neurons, nicotine boosts them. Newhouse cautioned that people concerned with memory loss should not take up smoking, however. “People with mild memory loss should not start smoking or using nicotine patches by themselves, because there are harmful effects of smoking and a medication such as nicotine should only be used with a doctor’s supervision,” he said. “But this study provides strong justification for further research into the use of nicotine for people with early signs of memory loss.” Newhouse says the next step is seeing if nicotine can reverse memory loss in patients with early stages of Alzheimer’s.
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