Prostate Cancer Treated With Hormone, Radiation Combination

Advanced prostate cancer can be effectively treated with a combination of radiation and hormone therapy, according to a new study from Canadian and British researchers.

"These patients were often felt, in the past, to be incurable, because the disease has spread locally outside of the prostate, but not elsewhere in the body," study author Dr. Padraig Warde, deputy head of the Princess Margaret Hospital Cancer Program and a professor of radiation oncology at the University of Toronto, told HealthDay. "But they shouldn't be discarded, we are showing that going for a cure is worthwhile."

Warde's study involved more than 1,200 men with high-risk, or locally advanced, prostate cancer, who in the past were often treated with hormone therapy alone. They were given either hormone therapy alone or hormones in combination with radiation.

After seven years, researchers found that about two-thirds of the men who received hormone therapy alone were still alive, while 74 percent who got the combination were still alive. Twenty-six percent of the hormones-only group died from prostate cancer, but just 10 percent who had combination therapy died. The study was the first to show the combination treatment improved survival rates.

"Specifically, [combination therapy] reduces the risk of dying from prostate cancer 43 percent and the risk of dying overall by 23 percent," Warde said. He also told HealthDay that in addition, radiation side effects did not affect the patients'quality of life three years after being treated. However, Dr. Matthew R. Cooperberg, an assistant professor of urology at the University of California, San Francisco, told HealthDay the study does not determine what the best treatment is for high-risk prostate cancer. Warde said that in the past, patients were given hormone therapy for life, and radiation in lower doses. Now, hormone therapy is usually given for about two to three years, and radiation in higher, targeted doses. Most advanced prostate cancer patients are not surgery candidates because of tumor size, he said. "Whether the approach should be surgery possibly followed by radiation, is still the big open question that we need to answer," said Cooperberg. The report appeared in the Nov. 3 issue of The Lancet. 
1 2 Next
CONTRIBUTE TO THIS STORY
Print Article