Pseudomonas Aeruginosa, Hospital Bug, Targeted by Engineered E.Coli

Nosocomial infection and medical errors injure more people each year than flying, but many arent aware of the risks, the World Health Organization said Thursday.

Pseudomonas aeruginosa is a super bug that’s often picked up in hospitals and frequently deadly, especially in patients with weakened immune systems. But a according to a new report in Molecular Systems Biology, scientists have engineered a non-threatening e. coli bacteria with the tools to destroy it, reported CBS News.

While no clinical trials have yet to be performed, CBS News reported that Dr. Nazanin Saeidi and Dr. Choon Kit Wong of Nanyang Technological University in Singapore may have made a significant contribution to the fight against serious bacterial infections since there haven’t been any major advances in the development of antibiotics in decades and antibiotic bugs are on the rise.

Cubist Pharmaceuticals, Inc. also recently announced that the company will begin clinical trials of an intravenous antibiotic to fight urinary tract infections caused by Pseudomonas aeruginosa, according to a company press release. The company reported that it is also planning to roll out clinical testing for treatment of abdominal infections also caused by Pseudomonas aeruginosa.

Santosh Vetticaden, PhD, MD, chief medical officer of Cubist Pharmaceuticals, Inc. was quoted in the company’s press release as saying, “We are extremely pleased to be making such a significant advance in this program that offers promise for the treatment of certain Gram-negative infections." Pseudomonas aeruginosa is considered a Gram-negative bacteria.

One of the problems with fighting bacterial infections is their ability to resist treatment. Martin Cormican, a professor of bacteriology at NUI Galway School of Medicine was quoted by the IrishTimes.com as saying, “But what’s extraordinary is the extent to which bacteria will adapt to anything you throw at them. If you pour water into a cup the water isn’t clever because it took the shape of the cup. Likewise, the nature of bacteria is to adapt quickly, and because we have shaped the cup in a way that makes antibiotic resistance advantageous, the bacteria have taken that shape.” In related news, IrishTimes.com also reported that scientists are exploring how to kill dangerous bacteria using gaseous plasma technology.
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