Statins Found To Be Effective and Safe Over Long-Term, Study Finds

Statins, the cholesterol-lowering medications, have been found to be effective and safe, even when used for long periods of time, according to British researchers.

The 11-year study found that simvastatin (brand name Zocor) reduced the risk of cardiovascular disease by almost one-quarter.

Additionally, the researchers found no increase in illness or deaths from cancer or other non-vascular causes as a result of using the drug.

The study was led by Dr. Richard Bulbulia, a consultant vascular surgeon and research fellow in the clinical trial service unit at the University of Oxford in England.

"All those at increased vascular risk should start taking statins early and continue taking them long term," Bulbulia said, reports MedPage Today.

"This will maximize the reductions in heart attacks, strokes and other vascular diseases, and is safe," he said.

There are numerous other drugs in this class of medication, and Bulbulia said, "it seems reasonable to assume that [this study's findings] should hold true for other currently prescribed statins,” MedPage Today reports.

Other commonly used statins include Lipitor, Crestor and Mevacor.

The research was funded by the U.K. Medical Research Council, the British Heart Foundation, Merck & Co. and Roche Vitamins.

The study examined the long-term safety of simvastatin because some research suggested that the rates of some cancers and non-vascular health conditions were increased in people who had lower levels of LDL (bad) cholesterol. Initially, the study involved more than 20,500 people, aged between 40 and 80 years old, who had a high risk of heart disease and other cardiovascular problems for a trial of simvastatin versus a placebo. Half the group was randomly assigned to take 40 milligrams of simvastatin daily, while the other half took a placebo. At the end of the trial, study participants were encouraged to continue on their study treatment for as long as another six years. People taking simvastatin managed to reduce their "bad" cholesterol an average of 1 millimole per liter over five years. The researchers said that this reduction translated into a 23 percent drop in the risk of heart attack and stroke, and the benefit continued throughout the follow-up. Results of the study are published in the Nov. 23 online issue of The Lancet: http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2811%2961125-2/fulltext
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