Vitamin D Levels Linked To Lower Colon Cancer Risk

Vitamin D levels have been linked to a lower risk of colon and rectal cancers, following a new analysis of earlier research.

Vitamin D levels have been linked to a lower risk of colon and rectal cancers, following a new analysis of earlier research.

In 18 studies involving more than 10,000 people, colon cancer risk was as much as 33 percent lower in subjects with the highest blood levels of vitamin D.

This was compared to those with the lowest levels, found the researchers from The Sixth People's Hospital affiliated with Shanghai Jiao Tong University.

Those with the highest intake of vitamin D through supplements and food had 12 percent lower risk than those with the lowest intakes.

Senior author Dr. Huanlong Qin and his colleagues said the number of studies for analysis are still too few, reports Reuters.

Vitamin D has previously been linked to protection from various cancers, heart disease, diabetes and asthma, among other conditions.

Yet, how the vitamin might exert a beneficial effect is still poorly understood. Some evidence suggests that exceeding current recommended daily requirements may yield benefits.

Qin's team said up to 58 percent of U.S. adults and adolescents may have vitamin D deficiency, which is "an important health problem in the industrial world,” reports Reuters.

While there are biologically plausible mechanisms through which low vitamin D levels could increase colon cancer risk, studies have had mixed results so far, the researchers add.

Qin's group looked only at the strongest studies that investigated the relationship between vitamin D intake or blood levels of 25-hydroxyvitamin D, the active form in the body, and colorectal cancer, colon cancer or rectal cancer. They identified nine studies of vitamin D intake including 6,466 patients, four of which were conducted in the US, three in Europe, and two in Asia. Nine more studies, including 2,767 cases and 3,948 people in comparison groups, looked at blood levels of 25-hydroxyvitamin D. Six studies were conducted in the US, two in Europe and one in the US. One study included both vitamin D intake and blood levels of 25-hydroxyvitamin D. The researchers noted that the analysis’ limitations included the lack of uniform criteria for comparison groups across the various studies, Reuters report.   Another drawback was not all of the studies had information on vitamin D intake or its blood levels for individuals. The "lowest" and "highest" categories in different studies also varied significantly. The team say additional studies would be "highly desirable to enable more precise estimates and a better understanding of the role of vitamin D in colorectal cancer carcinogenesis," Reuters reports. The analysis was published in the Journal of Clinical Oncology.
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